Article
An observational and genetic investigation into the association between psoriasis and risk of malignancy.
Nature communications - 11 Sept 2024
Li Ruolin, Luo Wenjin, Chen Xiangjun, Zeng Qinglian, Yang Shumin, Wang Ping, Hu Jinbo, Chen Aijun
Abstract excerpt
The relationship between psoriasis and site-specific cancers remains unclear. Here, we aim to investigate whether psoriasis is causally associated with site-specific cancers. We use observational and genetic data from the UK Biobank, obtaining GWAS summary data, eQTL analysis data, TCGA data, and GTEx data from public datasets. We perform PheWAS, polygenic risk score analysis, and one-sample and two-sample...
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