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Article

Thirdhand smoke exposure promotes gastric tumor development in mouse and human

26 Aug 2024

Abstract excerpt

• Thirdhand smoke (THS) exposure significantly increased gastric tumor incidence in CC036 mice. • THS induced over-expression of ECM genes in primary CC036 gastric epithelial cells. • CC036 derived THS gene signature has clinical value in human gastric cancer. • THS induces EMT providing a potential mechanism for THS-induced gastric cancer. • THS increased oncogenic traits in THS-treated human gastric cancer cell...

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PMID: 39255676
DOI: 10.1016/j.envint.2024.108986

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