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Article

Multiomics analyses of the complex interplay between genetic variants, DNA methylation, and gene expression in COVID-19.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2025

Chen Guanjie, DeRoo Lisa A, Goodney Gabriel, Doumatey Ayo P, Zhou Jie, Adeyemo Adebowale A, Rotimi Charles N, Gaye Amadou

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which drove the 2019 coronavirus disease (COVID-19) pandemic, continues to engender inquiries into the role of host genetic factors in disease susceptibility. Despite the identification of over 1,000 genes potentially associated with SARS-CoV-2 and COVID-19, the mechanisms connecting genetic variants to phenotype remain elusive. To shed light on these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40591496
DOI: 10.1152/ajpheart.00206.2025
PMCID: PMC12288550

Genes

GLMP
PMF1
ARHGEF2
MEX3A
TMEM79

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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