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Article

COVID-19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene prevalence.

Journal of clinical laboratory analysis - 1 Jul 2021

Ponti Giovanni, Pastorino Lorenza, Manfredini Marco, Ozben Tomris, Oliva Gabriella, Kaleci Shaniko, Iannella Raffaele, Tomasi Aldo

Abstract excerpt

BACKGROUND: Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID-19 infection. The purpose of this review was to analyze the correlation between the prevalence of MTHFR C677 T gene polymorphism and COVID-19 incidence and mortality worldwide. METHODS: Data regarding MTHFR C677 T gene mutation were obtained from the interrogation of the Genome Aggregation Database...

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Source

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Identifiers

PMID: 34061414
DOI: 10.1002/jcla.23798
PMCID: PMC8209953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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