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Discovery of NRG1-VII: the myeloid-derived class of NRG1

29 Aug 2024

Abstract excerpt

The growth factor Neuregulin-1 (NRG1) has pleiotropic roles in proliferation and differentiation of the stem cell niche in different tissues. It has been implicated in gut, brain and muscle development and repair. Six isoform classes of NRG1 and over 28 protein isoforms have been previously described. Here we report a new class of NRG1, designated NRG1-VII to denote that these NRG1 isoforms arise from a...

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PMID: 39210279
DOI: 10.1186/s12864-024-10723-2

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