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Vancomycin-resistant Staphylococcus aureus (VRSA) can overcome the cost of antibiotic resistance and may threaten vancomycin's clinical durability.

PLoS pathogens - 1 Aug 2024

Blechman Samuel E, Wright Erik S

Abstract excerpt

Vancomycin has proven remarkably durable to resistance evolution by Staphylococcus aureus despite widespread treatment with vancomycin in the clinic. Only 16 cases of vancomycin-resistant S. aureus (VRSA) have been documented in the United States. It is thought that the failure of VRSA to spread is partly due to the fitness cost imposed by the vanA operon, which is the only known means of high-level resistance....

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Identifiers

PMID: 39207957
DOI: 10.1371/journal.ppat.1012422
PMCID: PMC11361437

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