Article
Evaluation of Salmonella enterica serovar Typhimurium and Choleraesuis slyA mutant strains for use in live attenuated oral vaccines.
Comparative immunology, microbiology and infectious diseases - 1 Sept 2011
Haneda Takeshi, Okada Nobuhiko, Kikuchi Yuji, Takagi Masami, Kurotaki Tetsuro, Miki Tsuyoshi, Arai Setsuo, Danbara Hirofumi
Abstract excerpt
SlyA protein plays a key role in virulence in Salmonella enterica. In this study, we evaluated the ability of the slyA mutant strain of S. enterica serovar Choleraesuis (S. choleraesuis) to protect against swine salmonellosis. Using a murine model infected with S. enterica serovar Typhimurium (S. typhimurium), we showed that the Salmonella strain with a deletion of slyA could be used as a highly immunogenic,...
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