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Clustered Regularly Interspaced Short Palindromic Repeats-Cas system regulates <i>Salmonella</i> virulence

2023-12-14

Abstract excerpt

<h4>Objectives</h4> Investigating the type 1-E CRISPR-Cas-mediated regulation of Salmonella pathogenesis. <h4>Methods</h4> We assessed the pathogenicity of the wild-type and CRISPR-Cas knockout strains using infection models. The mechanisms were elucidated using antimicrobial assays and expression analysis. <h4>Results</h4> CRISPR-Cas knockout strains were defective in invasion and proliferation in intestinal...

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Literature Corpus work: 50352048-806f-54fc-8a4a-b170b93c8600
DOI: 10.1101/2023.12.12.571267

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