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Repeat Next-Generation Sequencing (15-Gene Panel) in Unifocal, Synchronous, and Metachronous Non-Small-Cell Lung Cancer-A Single-Center Experience.

Current oncology (Toronto, Ont.) - 3 Aug 2024

Kuang Shelley, Chen Kaitlin, Sayal Sachin, Prabahan Gajeni, Rabey Mary R, Le Lisa W, Seto Andrew, Shepherd Frances A, Liu Geoffrey, Bradbury Penelope, Sacher Adrian G, Law Jennifer H, Sabatini Peter, Stockley Tracy L, Tsao Ming S, Leighl Natasha B

Abstract excerpt

In advanced non-squamous non-small-cell lung cancer (NSCLC), routine testing with next-generation sequencing (NGS) is recommended to identify actionable genomic alterations (AGAs). The therapeutic implications of repeated NGS testing on synchronous and metachronous tumors are unclear. Between February 2017 and October 2020, NSCLC samples from a single institution were reflex-tested using a targeted 15-gene NGS...

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Identifiers

PMID: 39195317
DOI: 10.3390/curroncol31080334
PMCID: PMC11352737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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