Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Cytomegalovirus UL84 Interacts with an RNA Stem-Loop Sequence Found within the RNA/DNA Hybrid Region of ori Lyt

26 Apr 2007

Abstract excerpt

Human cytomegalovirus (HCMV) lytic DNA replication is initiated at the complex cis-acting oriLyt region, which spans nearly 3 kb. DNA synthesis requires six core proteins together with UL84 and IE2. Previously, two essential regions were identified within oriLyt. Essential region I (nucleotides [nt] 92209 to 92573) can be replaced with the constitutively active simian virus 40 promoter, which in turn eliminates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Mycobacterium research and diagnosis
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17459920
DOI: 10.1128/jvi.00058-07

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Cytomegalovirus UL84 Interacts with an RNA Stem-Loop Sequence Found within the RNA/DNA Hybrid Region of ori LytPMID 17459920Read ↗

Evidence that the UL84 gene product of human cytomegalovirus is essential for promoting oriLyt-dependent DNA replication and formation of replication compartments in cotransfection assaysSemantic proximity Read ↗

Boundaries and structure of human cytomegalovirus oriLyt, a complex origin for lytic-phase DNA replicationSemantic proximity Read ↗

Human cytomegalovirus UL84 oligomerization and heterodimerization domains act as transdominant inhibitors of oriLyt-dependent DNA replication: evidence that IE2-UL84 and UL84-UL84 interactions are required for lytic DNA replication.Semantic proximity Read ↗

Analysis of Human Cytomegalovirus <i>ori</i> Lyt Sequence Requirements in the Context of the Viral GenomeSemantic proximity Read ↗

Identification of Persistent RNA-DNA Hybrid Structures within the Origin of Replication of Human CytomegalovirusSemantic proximity Read ↗

G-quadruplex as an essential structural element in cytomegalovirus replication originSemantic proximity Read ↗

Human Cytomegalovirus DNA Replication Requires Transcriptional Activation via an IE2- and UL84-Responsive Bidirectional Promoter Element within <i>ori</i> LytSemantic proximity Read ↗

Initiation of Epstein-Barr Virus Lytic Replication Requires Transcription and the Formation of a Stable RNA-DNA Hybrid Molecule at OriLytSemantic proximity Read ↗

Characteristics of Immediate-Early 2 (IE2) and UL84 Proteins in UL84-Independent Strains of Human Cytomegalovirus (HCMV).Semantic proximity Read ↗

Analysis of the interactions of viral and cellular factors with human cytomegalovirus lytic origin of replication, oriLytSemantic proximity Read ↗

The IE2 60-Kilodalton and 40-Kilodalton Proteins Are Dispensable for Human Cytomegalovirus Replication but Are Required for Efficient Delayed Early and Late Gene Expression and Production of Infectious VirusSemantic proximity Read ↗

Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.