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Multitrait Genetic Analysis Identifies Novel Pleiotropic Loci for Depression and Schizophrenia in East Asians.

Schizophrenia bulletin - 8 May 2025

Song Yingchao, Li Linzehao, Jiang Yue, Peng Bichen, Jiang Hengxuan, Chao Zhen, Chang Xiao

Abstract excerpt

BACKGROUND AND HYPOTHESIS: While genetic correlations, pleiotropic loci, and shared genetic mechanisms of psychiatric disorders have been extensively studied in European populations, the investigation of these factors in East Asian populations has been relatively limited. STUDY DESIGN: To identify novel pleiotropic risk loci for depression and schizophrenia (SCZ) in East Asians. We utilized the most comprehensive...

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Identifiers

PMID: 39190819
DOI: 10.1093/schbul/sbae145
PMCID: PMC12061663

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