Article
Whole-genome sequencing-based genetic diversity, transmission dynamics, and drug-resistant mutations in Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia.
Frontiers in public health - 1 Jan 2024
Chekesa Basha, Singh Harinder, Gonzalez-Juarbe Norberto, Vashee Sanjay, Wiscovitch-Russo Rosana, Dupont Christopher L, Girma Musse, Kerro Oudessa, Gumi Balako, Ameni Gobena
Abstract excerpt
Background: Extrapulmonary tuberculosis (EPTB) refers to a form of Tuberculosis (TB) where the infection occurs outside the lungs. Despite EPTB being a devastating disease of public health concern, it is frequently overlooked as a public health problem. This study aimed to investigate genetic diversity, identify drug-resistance mutations, and trace ongoing transmission chains. Methods: A cross-sectional study was...
Topics
- Humans
- Ethiopia
- Mycobacterium tuberculosis
- Whole Genome Sequencing
- Cross-Sectional Studies
- Genetic Variation
- Mutation
- Adult
- Male
- Female