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Article

First-line drug-resistant tuberculosis among children under 15 years in Ethiopia: insights from phenotypic and whole-genome sequencing approaches.

BMC infectious diseases - 31 Mar 2026

Abebaw Yeshiwork, Ayele Abaysew, Ghodousi Arash, Alemayehu Dawit Hailu, Gebremicael Gebremedhin, Diriba Getu, Seid Getachew, Cabibbe Andrea Maurizio, Abebe Markos, Sheth Anandi, Argaw Rahel, Abegaz Woldaregay Erku

Abstract excerpt

BACKGROUND: Childhood drug-resistant tuberculosis is often underdiagnosed and inadequately characterized due to the paucibacillary nature of the disease. This study aimed to assess resistance to first-line anti-tuberculosis drugs in children using phenotypic drug susceptibility testing and whole-genome sequencing. METHODS: A retrospective-prospective study was conducted on culture-confirmed childhood tuberculosis...

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Identifiers

PMID: 41918080
DOI: 10.1186/s12879-026-13206-9
PMCID: PMC13162396

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