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Genetic diversity and drug resistance profiles of Mycobacterium tuberculosis among Ethiopian children as determined by whole-genome sequencing.

Microbiology spectrum - 7 Apr 2026

Abebaw Yeshiwork, Ayele Abaysew, Alemayehu Dawit Hailu, Gebremicael Gebremedhin, Diriba Getu, Weldemariam Atsbeha Gebreegziabxier, Zerihun Betselot, Moga Shewki, Adnew Bethlehem, Melaku Kalkidan, Getahun Muluwork, Argaw Rahel, Sheth Anandi, Abebe Markos, Abegaz Woldaregay Erku

Abstract excerpt

Ethiopia ranks 30th among the tuberculosis (TB) burden countries, with children representing a significant yet understudied population group. This study aims to investigate the genetic diversity and drug-resistant profile among Ethiopian children. We included children under 15 years of age diagnosed with culture-confirmed pulmonary TB/drug-resistant TB between January 2017 and June 2023. Phenotypic drug...

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PMID: 41757911
DOI: 10.1128/spectrum.02736-25
PMCID: PMC13055266

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