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Article

Knockout of the WD40 domain of ATG16L1 enhances foot and mouth disease virus replication

23 Aug 2024

Abstract excerpt

The WD40 domain is one of the most abundant domains and is among the top interacting domains in eukaryotic genomes. The WD40 domain of ATG16L1 is essential for LC3 recruitment to endolysosomal membranes during non-canonical autophagy, but dispensable for canonical autophagy. Canonical autophagy was utilized by FMDV, while the relationship between FMDV and non-canonical autophagy is still elusive. In the present...

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PMID: 39179961
DOI: 10.1186/s12864-024-10703-6

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