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Article

Foot-and-mouth disease virus downregulates vacuolar protein sorting 28 to promote viral replication

11 Aug 2023

Abstract excerpt

ABSTRACT Vacuolar protein sorting 28 (Vps28), a component of the ESCRT-I (endosomal sorting complex required for transport I), plays an important role in the pathogen life cycle. Here, we investigated the reciprocal regulation between Vps28 and the foot-and-mouth disease virus (FMDV). Overexpression of Vps28 decreased FMDV replication. On the contrary, the knockdown of Vps28 increased viral replication....

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Identifiers

PMID: 37565750
DOI: 10.1128/jvi.00181-23

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