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Article

Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia.

Biology open - 15 Sept 2024

Lints Robyn, Walker Christina A, Delfi Omid, Prouse Matthew, PohLui De Silva Mandy, Bohlander Stefan K, Wood Andrew C

Abstract excerpt

RUNX1::RUNX1T1 (R::RT1) acute myeloid leukaemia (AML) remains a clinical challenge, and further research is required to model and understand leukaemogenesis. Previous zebrafish R::RT1 models were hampered by embryonic lethality and low penetrance of the malignant phenotype. Here, we overcome this by developing an adult zebrafish model in which the human R::RT1 isoform 9a is co-expressed with the frequently...

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Identifiers

PMID: 39177514
DOI: 10.1242/bio.060523
PMCID: PMC11381922

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