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Article

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

19 May 2015

Abstract excerpt

Liver cancer stem cells (CSCs) harbour self-renewal and differentiation properties, accounting for chemotherapy resistance and recurrence. However, the molecular mechanisms to sustain liver CSCs remain largely unknown. In this study, based on analysis of several hepatocellular carcinoma (HCC) transcriptome datasets and our experimental data, we find that C8orf4 is weakly expressed in HCC tumours and liver CSCs....

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PMID: 25985737
DOI: 10.1038/ncomms8122

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