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Unveiling the influence of lipidomes on inflammatory bowel disease: a bidirectional mendelian randomization study

11 Apr 2025

Abstract excerpt

BACKGROUND: Plasma lipid homeostasis is pivotal in maintaining intestinal health. Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD) as distinct subtypes, manifests unique metabolic signatures. However, the specific roles of lipids in the pathogenesis and therapeutic targeting of IBD remain inadequately explored. This study aims to delineate the genetic influences of...

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PMID: 40217472
DOI: 10.1186/s12876-025-03858-3

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