Mid-pass whole-genome sequencing in a Malagasy cohort uncovers body composition associations.

doi:10.1016/j.xhgg.2024.100343

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Article

Mid-pass whole-genome sequencing in a Malagasy cohort uncovers body composition associations.

HGG advances - 10 Oct 2024

Hamid Iman, Raveloson Séverine Nantenaina Stéphie, Spiral Germain Jules, Ravelonjanahary Soanorolalao, Raharivololona Brigitte Marie, Randria José Mahenina, Zafimaro Mosa, Randriambola Tsiorimanitra Aimée, Andriantsoa Rota Mamimbahiny, Andriamahefa Tojo Julio, Rafidison Bodonomena Fitahiana Laza, Mughal Mehreen, Emde Anne-Katrin, Hendershott Melissa, LeBaron von Baeyer Sarah, Wasik Kaja A, Ranaivoarisoa Jean Freddy, Yerges-Armstrong Laura, Castel Stephane E, Rakotoarivony Rindra

Abstract excerpt

The majority of human genomic research studies have been conducted in European-ancestry cohorts, reducing the likelihood of detecting potentially novel and globally impactful findings. Here, we present mid-pass whole-genome sequencing data and a genome-wide association study in a cohort of 264 self-reported Malagasy individuals from three locations on the island of Madagascar. We describe genetic variation in...

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Identifiers

PMID: 39169618
DOI: 10.1016/j.xhgg.2024.100343
PMCID: PMC11415767

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