Article
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.
Cell - 31 Oct 2019
Gurdasani Deepti, Carstensen Tommy, Fatumo Segun, Chen Guanjie, Franklin Chris S, Prado-Martinez Javier, Bouman Heleen, Abascal Federico, Haber Marc, Tachmazidou Ioanna, Mathieson Iain, Ekoru Kenneth, DeGorter Marianne K, Nsubuga Rebecca N, Finan Chris, Wheeler Eleanor, Chen Li, Cooper David N, Schiffels Stephan, Chen Yuan, Ritchie Graham R S, Pollard Martin O, Fortune Mary D, Mentzer Alex J, Garrison Erik, Bergström Anders, Hatzikotoulas Konstantinos, Adeyemo Adebowale, Doumatey Ayo, Elding Heather, Wain Louise V, Ehret Georg, Auer Paul L, Kooperberg Charles L, Reiner Alexander P, Franceschini Nora, Maher Dermot, Montgomery Stephen B, Kadie Carl, Widmer Chris, Xue Yali, Seeley Janet, Asiki Gershim, Kamali Anatoli, Young Elizabeth H, Pomilla Cristina, Soranzo Nicole, Zeggini Eleftheria, Pirie Fraser, Morris Andrew P, Heckerman David, Tyler-Smith Chris, Motala Ayesha A, Rotimi Charles, Kaleebu Pontiano, Barroso Inês, Sandhu Manj S
Abstract excerpt
Genomic studies in African populations provide unique opportunities to understand disease etiology, human diversity, and population history. In the largest study of its kind, comprising genome-wide data from 6,400 individuals and whole-genome sequences from 1,978 individuals from rural Uganda, we find evidence of geographically correlated fine-scale population substructure. Historically, the ancestry of modern...
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