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Article

Clinical and molecular correlates of tumor aneuploidy in metastatic non-small cell lung cancer.

Scientific reports - 21 Aug 2024

Spurr Liam F, Pitroda Sean P

Abstract excerpt

Recent studies have linked elevated tumor aneuploidy to anti-tumor immune suppression and adverse survival following immunotherapy. Herein, we provide supportive evidence for tumor aneuploidy as a biomarker of response to immunotherapy in patients with non-small cell lung cancer (NSCLC). We identify a dose-response relationship between aneuploidy score and patient outcomes. In two independent NSCLC cohorts...

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Identifiers

PMID: 39169079
DOI: 10.1038/s41598-024-66062-5
PMCID: PMC11339421

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