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Article

Influence of the glutamate-glutamine cycle on valproic acid-associated hepatotoxicity in pediatric patients with epilepsy.

Clinical toxicology (Philadelphia, Pa.) - 1 Jun 2024

Ma Linfeng, Zhu Jingwei, Kong Xiaoni, Chen Li, Du Jiangdong, Yang Liping, Wang Dan, Wang Zhe

Abstract excerpt

INTRODUCTION: Although valproic acid is generally well tolerated, hepatotoxicity is a common side effect in patients receiving long-term treatment. However, the mechanisms underlying valproic acid-associated hepatotoxicity remain elusive. METHODS: To investigate the mechanisms and explore the potential risk factors for valproic acid-associated hepatotoxicity, 165 age-matched pediatric patients were recruited for...

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Identifiers

PMID: 38913595
DOI: 10.1080/15563650.2024.2366920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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