Perioperative exacerbation of valproic acid-associated hyperammonemia: a clinical and genetic analysis.

doi:10.1213/ANE.0b013e318228a001

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Article

Perioperative exacerbation of valproic acid-associated hyperammonemia: a clinical and genetic analysis.

Anesthesia and analgesia - 1 Oct 2011

Bezinover Dmitri, Postula Marek, Donahue Kathleen, Bentzen Brian, McInerney James, Janicki Piotr K

Abstract excerpt

We present a case of significant deterioration of chronic hyperammonemia after general anesthesia for neurosurgery despite aggressive treatment. Preoperative evaluation demonstrated that hyperammonemia was most likely related to valproic acid treatment. Genomic analysis revealed that the patient was heterozygotic for a missense polymorphism in the carbamoyl phosphate synthase 1 gene (4217C>A, rs1047891). This...

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PMID: 21821508
DOI: 10.1213/ANE.0b013e318228a001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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