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Article

Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer.

Cell death & disease - 20 Aug 2024

Canu Valeria, Vaccarella Sebastiano, Sacconi Andrea, Pulito Claudio, Goeman Frauke, Pallocca Matteo, Rutigliano Daniela, Lev Sima, Strano Sabrina, Blandino Giovanni

Abstract excerpt

Triple negative breast cancer (TNBC) is an aggressive disease which currently has no effective therapeutic targets and prominent biomarkers. The Sperm Associated antigen 5 (SPAG5) is a mitotic spindle associated protein with oncogenic function in several human cancers. In TNBC, increased SPAG5 expression has been associated with tumor progression, chemoresistance, relapse, and poor clinical outcome. Here we show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39164278
DOI: 10.1038/s41419-024-06987-x
PMCID: PMC11336084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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