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Single‐cell transcriptomic analysis reveals that the APP – CD74 axis promotes immunosuppression and progression of testicular tumors

19 Aug 2024

Abstract excerpt

Testicular tumors represent the most common malignancy among young men. Nevertheless, the pathogenesis and molecular underpinning of testicular tumors remain largely elusive. We aimed to delineate the intricate intra-tumoral heterogeneity and the network of intercellular communication within the tumor microenvironment. A total of 40,760 single-cell transcriptomes were analyzed, encompassing samples from six...

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PMID: 39161125
DOI: 10.1002/path.6343

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