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Superhydrophobic Array Devices for the Enhanced Formation of 3D Cancer Models

16 Aug 2024

Abstract excerpt

During the metastatic cascade, cancer cells travel through the bloodstream as circulating tumor cells (CTCs) to a secondary site. Clustered CTCs have greater shear stress and treatment resistance, yet their biology remains poorly understood. We therefore engineered a tunable superhydrophobic array device (SHArD). The SHArD-C was applied to culture a clinically relevant model of CTC clusters. Using our device, we...

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PMID: 39150223
DOI: 10.1021/acsnano.4c08132

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