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Article

Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes

1 Jan 2012

Abstract excerpt

Hematogenous metastasis, the process of cancer cell migration from a primary to distal location via the bloodstream, typically leads to a poor patient prognosis. Selectin proteins hold promise in delivering drug-containing nanocarriers to circulating tumor cells (CTCs) in the bloodstream, due to their rapid, force-dependent binding kinetics. However, it is challenging to deliver such nanocarriers while avoiding...

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PMID: 25152752
DOI: 10.1155/2012/831263

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