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Association between JAK2V617F variable allele frequency and risk of thrombotic events in patients with myeloproliferative neoplasms

14 Aug 2024

Abstract excerpt

Abstract Background Myeloproliferative neoplasms (MPNs) are a group of chronic disorders of the bone marrow characterised by the overproduction of clonal myeloid stem cells. The most common driver mutation found in MPNs is a point mutation on exon 14 of the JAK2 gene, JAK2V617F. Various studies have suggested that measuring the variable allele frequency (VAF) of JAK2V617F may provide useful insight regarding...

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PMID: 39138783
DOI: 10.1007/s11845-024-03776-5

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