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Analysis of the effect of HDAC inhibitors on the formation of the HIV reservoir

13 Aug 2024

Abstract excerpt

ABSTRACT The HIV reservoir is more dynamic than previously thought with around 70% of the latent reservoir originating from viruses circulating within 1 year of the initiation of antiretroviral therapy (ART). In an ex vivo model system of HIV latency, it was reported that early exposure to class I histone deacetylase (HDAC) inhibitors might prevent these more recently infected cells from entering a state of...

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PMID: 39136440
DOI: 10.1128/mbio.01632-24

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