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Article

Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors

25 Aug 2009

Abstract excerpt

OBJECTIVES: A family of histone deacetylases (HDACs) mediates chromatin remodeling, and repression of gene expression. Deacetylation of histones within the HIV-1 long terminal repeat (LTR) by HDACs plays a key role in the maintenance of latency, whereas acetylation of histones about the LTR is linked to proviral expression and escape of HIV from latency. Global HDAC inhibition may adversely affect host gene...

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PMID: 19590405
DOI: 10.1097/qad.0b013e32832ec1dc

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