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Regulation of the hematopoietic stem cell pool by C-Kit–associated trogocytosis

8 Aug 2024

Abstract excerpt

Hematopoietic stem cells (HSCs) are routinely mobilized from the bone marrow (BM) to the blood circulation for clinical transplantation. However, the precise mechanisms by which individual stem cells exit the marrow are not understood. This study identified cell-extrinsic and molecular determinants of a mobilizable pool of blood-forming stem cells. We found that a subset of HSCs displays macrophage-associated...

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PMID: 39116219
DOI: 10.1126/science.adp2065

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