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Automatic quantification of HER2 gene amplification in invasive breast cancer from chromogenic in situ hybridization whole slide images

21 Nov 2019

Abstract excerpt

Human epidermal growth factor receptor 2 (HER2), a transmembrane tyrosine kinase receptor encoded by the ERBB2 gene on chromosome 17q12, is a predictive and prognostic biomarker in invasive breast cancer (BC). Approximately 20% of BC are HER2-positive as a result of ERBB2 gene amplification and overexpression of the HER2 protein. Quantification of HER2 is performed routinely on all invasive BCs, to assist in...

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PMID: 31763355
DOI: 10.1117/1.jmi.6.4.047501

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