Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel human acute myeloid leukemia cell line SDEY-AML1 with KMT2A: MLLT3, IKZF1: EVX1 fusions exhibits high tumorigenicity in NSG mice.

Scientific reports - 8 Feb 2026

Yang Chenwei, Zhang Weiliang, Wu Yijun, Liu Xin, Gao Li, Zhang Hui, Li Zhiheng, Hu Shaoyan

Abstract excerpt

Human leukemia cell lines play a crucial role in leukemia research, particularly in understanding the pathogenesis of acute leukemia and developing novel therapeutic strategies. We here describe the generation of a novel monocytic cell line SDEY-AML1, harboring alterations in KMT2A::MLLT3, IKZF1::EVX1, ETV6, and TP53 double mutations, and its biological characteristics. We established a cell line, SDEY-AML1, from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Myeloid-Lymphoid Leukemia Protein

Share to Oncogene Proteins, Fusion

Source

Open in PubMed Open full text

Identifiers

PMID: 41656387
DOI: 10.1038/s41598-026-39353-2
PMCID: PMC12949064

Genes

EVX1
IKZF1
KMT2A
MLLT3
ETV6
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel human acute myeloid leukemia cell line SDEY-AML1 with KMT2A: MLLT3, IKZF1: EVX1 fusions exhibits high tumorigenicity in NSG mice.PMID 41656387Read ↗

EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environmentSemantic proximity Read ↗

Atypical CML: diagnosis and treatment.Semantic proximity Read ↗

Revumenib for patients with acute leukemia: a new tool for differentiation therapySemantic proximity Read ↗

Exploration of ETV6::ABL1-positive AML with concurrent NPM1 and FLT3-ITD mutations.Semantic proximity Read ↗

Deciphering the Complexities of Acute Myeloid Leukemia: Emerging Roles of Epithelial to Mesenchymal Transition Transcription Factors (EMT-TFs) in Disease ProgressionSemantic proximity Read ↗

Molecular and clinical characterization of ETNK1-mutated myeloid neoplasms: the Mayo Clinic experience.Semantic proximity Read ↗

ETNK1 mutation occurs in a wide spectrum of myeloid neoplasms and is not specific for atypical chronic myeloid leukemia.Semantic proximity Read ↗

Whole genome and transcriptome analysis of a novel AML cell line with a normal karyotype.Semantic proximity Read ↗

The Role of Epithelial-to-Mesenchymal Transition Transcription Factors (EMT-TFs) in Acute Myeloid Leukemia ProgressionSemantic proximity Read ↗

Acute erythroid leukemia is enriched in NUP98 fusions: a report from the Children’s Oncology GroupSemantic proximity Read ↗

NPM1-Mutated AML: Deciphering the Molecular and Clinical Puzzle in the Era of Novel Treatment StrategiesSemantic proximity Read ↗

Clinical and molecular consequences of fusion genes in myeloid malignanciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.