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Synovial expression of glucocorticoid receptor parallels fibroblast activation in patients with rheumatoid arthritis

6 Aug 2024

Abstract excerpt

BACKGROUND: Hypocortisolemia is associated with increased expression of NR3C1 (glucocorticoid receptor, GR) in blood cells. As endogenous cortisol production is decreased in some RA patients, we tested the hypothesis that GR may be aberrantly expressed in rheumatoid synovium. METHODS: We defined the cellular pattern of NR3C1 synovial expression using human and mouse single-cell RNA-sequencing data. Bulk synovial...

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PMID: 39105347
DOI: 10.1111/eci.14298

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