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Article

Machine learning based metabolomic and genetic profiles for predicting multiple brain phenotypes.

Journal of translational medicine - 3 Dec 2024

Zhang Xueli, Huang Yu, Liu Shunming, Ma Shuo, Li Min, Zhu Zhuoting, Wang Wei, Zhang Xiayin, Liu Jiahao, Tang Shulin, Hu Yijun, Ge Zongyuan, Yu Honghua, He Mingguang, Shang Xianwen

Abstract excerpt

BACKGROUND: It is unclear regarding the association between metabolomic state/genetic risk score(GRS) and brain volumes and how much of variance of brain volumes is attributable to metabolomic state or GRS. METHODS: Our analysis included 8635 participants (52.5% females) aged 40-70 years at baseline from the UK Biobank. Metabolomic profiles were assessed using nuclear magnetic resonance at baseline (between 2006...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39627804
DOI: 10.1186/s12967-024-05868-3
PMCID: PMC11613467

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