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Targeting undruggable phosphatase overcomes trastuzumab resistance by inhibiting multi-oncogenic kinases

14 Jul 2024

Abstract excerpt

AIMS: cancers. The role of protein tyrosine phosphatases (PTPs) in trastuzumab resistance is not well understood. In this study, we aim to identify pivotal PTPs affecting trastuzumab resistance and devise a novel counteracting strategy. METHODS: breast cancer. Tyrosine kinase (TK) arrays were used to identify kinases that linked to protein tyrosine phosphate receptor type O (PTPRO)-enhanced trastuzumab...

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PMID: 39094301
DOI: 10.1016/j.drup.2024.101118

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