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Article

Isolation of midgut escape mutants of two American genotype dengue 2 viruses from Aedes aegypti.

Virology journal - 12 Aug 2013

Khoo Cynthia C H, Doty Jeffrey B, Held Nicole L, Olson Ken E, Franz Alexander W E

Abstract excerpt

BACKGROUND: Several studies have shown that American genotype dengue 2 viruses (DENV2) have reduced viral fitness in the mosquito vector, Aedes aegypti, compared to other DENV2 genotypes. Diminished replication efficiency or inability to efficiently traverse membrane barriers encompassing organs such as the midgut or salivary glands are considered major factors negatively impacting viral fitness in the mosquito....

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Identifiers

PMID: 23937713
DOI: 10.1186/1743-422X-10-257
PMCID: PMC3751248

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