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Article

Association between polygenic risk for schizophrenia and retinal morphology: A cross-sectional analysis of the United Kingdom Biobank.

Psychiatry research - 1 Sept 2024

Blose Brittany A, Silverstein Steven M, Stuart Kelsey V, Keane Pearse A, Khawaja Anthony P, Wagner Siegfried K

Abstract excerpt

We examined the relationship between genetic risk for schizophrenia (SZ), using polygenic risk scores (PRSs), and retinal morphological alterations. Retinal structural and vascular indices derived from optical coherence tomography (OCT) and color fundus photography (CFP) and PRSs for SZ were analyzed in N = 35,024 individuals from the prospective cohort study, United Kingdom Biobank (UKB). Results indicated that...

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PMID: 39079374
DOI: 10.1016/j.psychres.2024.116106

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CFP

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