Signature of Altered Retinal Microstructures and Electrophysiology in Schizophrenia Spectrum Disorders Is Associated With Disease Severity and Polygenic Risk.

doi:10.1016/j.biopsych.2024.04.014

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Article

Signature of Altered Retinal Microstructures and Electrophysiology in Schizophrenia Spectrum Disorders Is Associated With Disease Severity and Polygenic Risk.

Biological psychiatry - 15 Nov 2024

Boudriot Emanuel, Gabriel Vanessa, Popovic David, Pingen Pauline, Yakimov Vladislav, Papiol Sergi, Roell Lukas, Hasanaj Genc, Xu Simiao, Moussiopoulou Joanna, Priglinger Siegfried, Kern Christoph, Schulte Eva C, Hasan Alkomiet, Pogarell Oliver, Falkai Peter, Schmitt Andrea, Schworm Benedikt, Wagner Elias, Keeser Daniel, Raabe Florian J

Abstract excerpt

BACKGROUND: Optical coherence tomography and electroretinography studies have revealed structural and functional retinal alterations in individuals with schizophrenia spectrum disorders (SSDs). However, it remains unclear which specific retinal layers are affected; how the retina, brain, and clinical symptomatology are connected; and how alterations of the visual system are related to genetic disease risk....

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PMID: 38679358
DOI: 10.1016/j.biopsych.2024.04.014

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