Article
Adaptive truncation of the S gene in IBV during chicken embryo passaging plays a crucial role in its attenuation.
PLoS pathogens - 1 Jul 2024
Liang Rong, Liu Kangchengyin, Li Yingfei, Zhang Xuehui, Duan Linqing, Huang Min, Sun Lu, Yuan Fang, Zhao Jing, Zhao Ye, Zhang Guozhong
Abstract excerpt
Like all coronaviruses, infectious bronchitis virus, the causative agent of infectious bronchitis in chickens, exhibits a high mutation rate. Adaptive mutations that arise during the production of live attenuated vaccines against IBV often decrease virulence. The specific impact of these mutations on viral pathogenicity, however, has not been fully elucidated. In this study, we identified a mutation at the 3' end...
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