Article
Genomic characteristics and changes of avian infectious bronchitis virus strain CK/CH/LDL/97I after serial passages in chicken embryos.
Intervirology - 1 Jan 2014
Zhao Fei, Han Zongxi, Zhang Tingting, Shao Yuhao, Kong Xiangang, Ma Huijie, Liu Shengwang
Abstract excerpt
BACKGROUND: We previously attenuated the infectious bronchitis virus (IBV) strain CK/CH/LDL/97I and found that it can convey protection against the homologous pathogenic virus. OBJECTIVE: To compare the full-length genome sequences of the Chinese IBV strain CK/CH/LDL/97I and its embryo-passaged, attenuated level to identify sequence substitutions responsible for the attenuation and define markers of attenuation....
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