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Article

S gene and 5a accessory gene are responsible for the attenuation of virulent infectious bronchitis coronavirus

1 May 2019

Abstract excerpt

To explore the critical genes associated with infectious bronchitis virus (IBV) virulence, we compared the genome sequences of virulent YN strain and its attenuated strain aYN. Accumulation of mutations in the S gene and the accessory gene 5a were observed, suggesting a potential role in the loss of viral pathogenicity. Two recombinant IBVs (rIBVs) with replacement of the S gene or 5a with corresponding regions...

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Identifiers

PMID: 31078931
DOI: 10.1016/j.virol.2019.04.014

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