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Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2

22 Jun 2024

Abstract excerpt

Antibodies play a pivotal role in protecting from SARS-CoV-2 infection, but their efficacy is challenged by the continuous emergence of viral variants. In this study, we describe two broadly neutralizing antibodies cloned from the memory B cells of a single convalescent individual after infection with ancestral SARS-CoV-2. Cv2.3194, a resilient class 1 anti-RBD antibody, remains active against Omicron...

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PMID: 39071888
DOI: 10.1016/j.isci.2024.110354

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