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Genetic Variants of the Receptor Activator Nuclear of κB Ligand Gene Increase the Risk of Rheumatoid Arthritis in a Mexican Mestizo Population: A Case-Control Study.

Genes - 11 Jul 2024

Arturo Nava-Valdivia Cesar, Ivan Gamez-Nava Jorge, Betsabe Contreras-Haro, Emilio Perez-Guerrero Edsaul, Yussef Esparza-Guerrero, Alejandra Rodriguez-Jimenez Norma, Tonatiuh Gonzalez-Heredia, Alejandra Villagomez-Vega, Ismael Nuño-Arana, Elena Totsuka-Sutto Sylvia, Manuel Ponce-Guarneros Juan, Heriberto Jacobo-Cuevas, Gerardo Alvarez-Ayala Efren, Laura Gonzalez-Lopez, Miriam Saldaña-Cruz Ana

Abstract excerpt

The Receptor Activator Nuclear of κB Ligand (RANKL) plays an important function in immune responses, activating osteoclast cells and unchanged bone resorption, which in turn leads to bone erosion and inflammation. Genetic variants in the promoter region of the RANKL gene could lead to a higher risk of rheumatoid arthritis (RA). OBJECTIVE: To assess the association of rs9533155 (-693C>G) and rs9533156 (-643T>C)...

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Identifiers

PMID: 39062686
DOI: 10.3390/genes15070907
PMCID: PMC11275863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Genetic Variants of the Receptor Activator Nuclear of κB Ligand Gene Increase the Risk of Rheumatoid Arthritis in a Mexican Mestizo Population: A Case-Control Study.PMID 39062686Read ↗

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