Article
Titin gene mutations are common in families with both peripartum cardiomyopathy and dilated cardiomyopathy.
European heart journal - 21 Aug 2014
van Spaendonck-Zwarts Karin Y, Posafalvi Anna, van den Berg Maarten P, Hilfiker-Kleiner Denise, Bollen Ilse A E, Sliwa Karen, Alders Mariëlle, Almomani Rowida, van Langen Irene M, van der Meer Peter, Sinke Richard J, van der Velden Jolanda, Van Veldhuisen Dirk J, van Tintelen J Peter, Jongbloed Jan D H
Abstract excerpt
AIM: Peripartum cardiomyopathy (PPCM) can be an initial manifestation of familial dilated cardiomyopathy (DCM). We aimed to identify mutations in families that could underlie their PPCM and DCM. METHODS AND RESULTS: We collected 18 families with PPCM and DCM cases from various countries. We studied the clinical characteristics of the PPCM patients and affected relatives, and applied a targeted next-generation...
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