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Article

Genome-wide characterization of circular RNAs in three rat models of pulmonary hypertension reveals distinct pathological patterns

10 Feb 2025

Abstract excerpt

BACKGROUND: Pulmonary hypertension (PH) is a devastating disease marked by elevated pulmonary artery pressure, resulting in right ventricular (RV) failure and mortality. Despite the identification of several dysregulated genes in PH, the involvement of circular RNAs (circRNAs), a subset of long noncoding RNAs, remains largely unknown. METHODS: In this study, high-throughput RNA sequencing was performed to analyze...

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PMID: 39930385
DOI: 10.1186/s12864-025-11239-z

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