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Article

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer.

Genomics, proteomics & bioinformatics - 15 Oct 2024

Zhang Rou, Hu Meng, Liu Yu, Li Wanmeng, Xu Zhiqiang, He Siyu, Lu Ying, Gong Yanqiu, Wang Xiuxuan, Hai Shan, Li Shuangqing, Qi Shiqian, Li Yuan, Shu Yang, Du Dan, Zhang Huiyuan, Xu Heng, Zhou Zongguang, Lei Peng, Chen Hai-Ning, Dai Lunzhi

Abstract excerpt

Magnesium (Mg) deficiency is associated with increased risk and malignancy in colorectal cancer (CRC), yet the underlying mechanisms remain elusive. Here, we used genomic, proteomic, and phosphoproteomic data to elucidate the impact of Mg deficiency on CRC. Genomic analysis identified 160 genes with higher mutation frequencies in Low-Mg tumors, including key driver genes such as KMT2C and ERBB3. Unexpectedly,...

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Source

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Identifiers

PMID: 39052867
DOI: 10.1093/gpbjnl/qzae053
PMCID: PMC11514849

Genes

ACTN4
DBN1
MMP2
APC
ERBB3
KMT2C
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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