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Magnesium deficiency with high calcium-to-magnesium ratio promotes a metastatic phenotype in the CT26 colon cancer cell line.

Magnesium research - 1 Aug 2020

Kumar Gopal, Chatterjee Prodyot K, Madankumar Swati, Mehdi Syed F, Xue Xiangying, Metz Christine N

Abstract excerpt

Magnesium (Mg) plays important roles in maintaining genomic stability and cellular redox. Mg also serves as nature's physiological calcium (Ca) channel antagonist, controlling intracellular Ca entry. Because Ca is the most important second messenger, its intracellular concentration is tightly regulated. Excess intracellular Ca can activate aberrant signaling pathways leading to the acquisition of pathological...

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PMID: 33210606
DOI: 10.1684/mrh.2020.0470

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