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Article

Investigating the causal relationship between 731 immune phenotypes and thyroid cancer risk: A bidirectional Mendelian randomization study.

Medicine - 17 Oct 2025

Bian Tingting, Zhang Yali, Lai Weiyi, Zhang Jianguo, Jiang Daishan, Liu Yifei

Abstract excerpt

Previous studies have demonstrated a significant correlation between immune cells and thyroid cancer (TC). Nevertheless, there remains uncertainty regarding whether this association indicates a causal relationship. We performed a bidirectional Mendelian randomization (MR) analysis to explore the causal relationship between 731 immune phenotypes and thyroid cancer. Our primary analytical method was the inverse...

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Topics

Humans
Thyroid Neoplasms
Mendelian Randomization Analysis
Phenotype
Genetic Predisposition to Disease
Risk Factors

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Identifiers

PMID: 41189243
DOI: 10.1097/MD.0000000000045072
PMCID: PMC12537243

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